$uv0rexant

[tomatos]

Orexin antagonist. 

Is there any place that sells this or is it a unicorn?

[cthruit]

Orexin antagonist. 

Is there any place that sells this or is it a unicorn?

I know of at least three places that sell it.  All three are located in the same country.  Would like to help more but apparently, under the rules, that's all I'm allowed to say.  Somebody correct me If I'm wrong.

[cthruit]

From Wikipedia:

$uv0rexant has been marketed in the United States, Canada, Australia, Russia, and Japan.  Although previously available, $uv0rexant appears to have been discontinued in Canada. It does not appear to be available in the United Kingdom or other European countries besides Russia.

[IceWizard]

Thanks for the update...

Ice

[cthruit]

It belongs to a class of drugs called Dual Orexin Receptor Antagonists (DORA). Drugs in this class include:

$uv0rexant (Bel$0mra) half-life 12 hours
L3mb0rexant (D@yvig0) half-life 17–55 hours
D@rid0rex@nt (Quv|v|q) half-life 8 hours

I would think that a half-life of 17-55 hours is going to produce a lot of next-day drowsiness but, OTOH, it might be what's needed to keep some people asleep for more than a few hours at a time. Eight hours half-life probably is not going to keep an insomniac asleep for the full eight hours but, OTOH, would be the best choice if next day drowsiness is absolutely not an option (heavy equipment operator, for example). Twelve hour half-life probably the best choice for most insomniacs.

---

I became interested in this class of drugs when I was fasting to lose weight (taking Mounj@ro by Rx). Some people report that these GLP-1 weight loss meds give them insomnia. I was having a hard time sleeping through the night even though I didn't have any trouble falling asleep. I had never had any trouble with sleep in the past, except intermittently when under acute stressful life situations. Researching this, I discovered that there is a phenomenon that one might term "Early Awakening due to Starvation Response." As it turns out, ketogenic dieters and intermittent fasters can also suffer from the same problem. The problem then, is not produced directly by the GLP-1, but is caused by the body’s response to prolonged caloric deficit. Summary of the process outlined here:

https://peterattiamd.com/how-fasting-can-impact-sleep/

TL;DR: Your caveman brain produces a hormone called OREXIN to get you up and moving to search for food before you starve to death.

There are many, many different types of problems with sleeping with many, many different causes and many, many different solutions. The class of drugs discussed here, Dual Orexin Receptor Antagonists, are the perfect solution if this is the cause of your insomnia.

[Charon]

tomatoes is this an emergency?

if so, use my email: untitlednonidentity@gmail.com


i can PM tomatoes.

But I have two family members, one with a brain bleed and my sister whom does not know the Lord. So I would do this tomorrow if that is okay.

[Charon]

good nite all,

houseshare and nephew may have covid again. i gotta go offline and keep praying. and for my sister and her husband. she hates me but i forgive her and i know what she is going thru and i want her husband saved and healed and my sister saved and to know God is handling this for her. Fear not.

[tomatos]

tomatoes is this an emergency?

if so, use my email: untitlednonidentity@gmail.com


i can PM tomatoes.

But I have two family members, one with a brain bleed and my sister whom does not know the Lord. So I would do this tomorrow if that is okay.

No not at all. Was just something that seemed worth trying as a safer alternative to benzos.

[tomatos]

I ended up finding a reliable source for this --- bio-japan.
Yay.