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Increasing bioavailability of benzo's
#34
(01-12-2018, 10:58 PM)invisiblejungle Wrote: Alp has dopaminergic effects, which is probably why it's the most-often abused benzo for recreational purposes.

Personally, I want to take benzos simply for the GABAergic effects, not for any euphoria. Loraz definitely feels like more of a pure GABAergic; no euphoria, just as Oldboy says. Same with bromaz and etiz. These are my 3 main benzos.

I can personally testify to the dopaminergic effects of Alp, invisible jungle. 
Over a decade ago a Sleep Specialist physician spent many months cycling me through all the benzos of the day to establish which had the most beneficial effect on my Willis-Ekbom Disease (Restless Legs Syndrome).  I remember him saying that the majority ended up settling on Clonaz.
But not for me. ALP was easily way more effective than any & everything else (and I didn't object to the mildly enjoyable ride to sleep either Blush) . 
He explained it away as " Whatever works for you. Everyone's different". 
The ALPs were later withdrawn Sad in favour of the new and wonderfully effective dopamine agonist drugs.
Itinitially prescribed for patients with Parkinsons, once they got out in the field it was discovered they worked amazingly well for people with with Willis-Ekbom/RLS too.
It was only in 2017 that I read about ALP being the only benzo to also exhibit mild D2 & D3 effects - Idea, finally the link with it's effectiveness with RLS was made.

Same Sleep Specialist also ordered my GP to prescribe Zolpidem for me (on an ongoing basis!) for RLS related sleep onset issues.
But after the ALPs...well, you know...10mg Zolpidem is a bit "Ho Hum" as far as I'm concerned  Rolleyes

Perhaps Alp's dopaminergic effects explain why it's the most-often abused benzo for recreational purposes. Undecided
I reckon you'd need to take a truck load of it before you'd get any dopamine reward/ impulse control / gambling / sex crazed effects kicking in.
You'd be GABA comatose way before then, I think.
Still, it'd make for some great dreams!!!! Big Grin....if you were only able to remember them Rolleyes  Big Grin  
R.
There's a difference between having an opinion and having an informed opinion.
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RE: Increasing bioavailability of benzo's - by Richardg8092 - 01-13-2018, 12:47 AM

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