12-06-2017, 08:45 AM
(12-05-2017, 06:57 PM)cmdline Wrote: what i dont get is there some sort of path in the mouth that benzos are absorbed more quickly ? it secrets saliva is there correlation to that,since while taking it under tongue or dissolwing in mouth eventually you still swallow it,empty stomach makes sense on almost any med to kick in faster as theres no food thus it goes straight into processing.
Also while at this topic is there any way to potentiate it or make last longer, since these days seems when under stress i could take twice the dosage but it does little to calm down, thou in many cases noticed that effects kick in later so guess thats because of food.So would be interested to hear more Rafterman.
Howdy C,
The underside of the tongue and the inside of the cheek are loaded with capillaries. Any lipid-soluble med can be quickly absorbed into the bloodstream by them, skipping the trip through the digestive tract. That is also why you will feel the effects sooner. I found that it is best to powder the meds first, whenever possible. There is a more complete absorption that way. In my experience, the effects appear stronger when taken sublingually, probably due to two reasons. The first would be that the onset is more distinct. When taken by swallowing, a person usually has to wait between 20-30 minutes to feel anything. By time that rolls around, they are probably off doing something else and not paying attention to the onset of the effects. When you go sublingually, you can usually feel the effects before you have time to move on to somewhere else. The second reason would be that the med is spared the deterioration that would be caused by the digestive system. As for bioavailability, I have tried it all. Cimetidine (Tagamet) is the only thing that even worked marginally for me, with the big exception of an empty stomach. With me, the effects of taking meds on an empty vs full stomach is like night and day. No food for six hours, particularly no protein...as protein is highly competitive with the meds for passage through the blood brain barrier. I know that it is sometimes impossible to be empty before a dose, but if you are feeling that your normal dose isn't making it anymore when you are under stress, I would definitely try for an empty stomach as often as possible. Many people say that an empty stomach is not important if you are taking the meds sublingually, but it is important. Even though the meds will never actually enter your stomach, what you have recently eaten will still compete for passage through the BBB into your brain. Let me know what you think. Thanks RM