06-22-2018, 01:35 PM
Firstly, a major shoutout to “LilRaquel” who posted a similar thread, regarding current availability issues of Etizolam. Reading said threat sparked an interest/a realization that despite having been a lifelong sufferer of SEVERE and comorbid anxiety disorders/neuroses, being seen by dozens of neurologists, psychiatrists, other specialists (related to insomnia), etc. etc. I at first intended to post a reply on LilRaquel’s thread, but I did not want to risk “hijacking” or “derailing” the purpose of that thread, which was more immediate in terms of priority, and also much more specific, as opposed to general thread on
Thienotriazolodiazepines, their uses, merits, detrements, and general distinction from benzodiazepines and other anxiety medications with a similar profile of side effects/effects, but a different chemical receptor binding site and very different pharmacology beneath the surface.
Below is what I had written with the intention of replying to another thread, rather than starting my
Own. If you have personal experience or knowledge of this medication or it’s class/sub-class, I am all ears! I intend to pursue this topic of research on my own, but I also want to benefit/enlighten as many members here as possible as I try to enlighten myself and determine ignorance said substance hasn’t viability as either a mono therapy or an adjunct to my current regimen. Please keep in mind while reading this post that the information below was initially intended as a reply to another thread, and this introduction was actually written last for contex.
As I read and learn more, I will continue to update this thread/edit my posts to reflect greater clarity, accessibility to a wider audience (as little jargon as possible), and in general to be as informative as possible. If something like this exists, please forgive my mistake, I still don’t have access to many features of the site, and I’m not 100% sure of how to cross-check for redundant/duplicate threads that need to be merged. If any of this is an issue please take whatever measures are necessary to right my mistakes and help me understand what I did wrong so I can avoid doing so in the future.
My original message/reaction to the concept of Thienotriazolodiazepines:
________________________________________________________________________________________________
WOW! As a chronic, lifelong sufferer of severe OCD, GAD, Social Anxiety, & Late-waking Insomnia (caused by anxiety... notice a tend? Haha) I’m now an adult patient in my early thirties, and in all my life, I have NEVER encountered this medicine or even class/sub-class in a clinical setting/discussion - though I did recognize it on a surface level, due to having encountered it in an “internet research” context, as well as possibly being advertised via one or more vendors that I’ve had positive working relationships with in the past.
(I will double-check this in case I’m already aware of a potential source that is in stock which may be of immediate aid you and others, though I’m not quite sure how I’d share the information without it being publicly visible/pontentially compromising, and thus it might not be in the best interest of this forum’s loyal & respected membership base as a whole. Furthermore, it being a schedule 1 substance in my state and a handful of others, despite it’s legal potential for prescription federally speaking, state laws greatly limit the likelihood that a vendor
I currently know of would be selling/stocking it)
I recognized it’s name & overall profile via the thread title, as being similar in etymology, chemical profile of physical/psychological effects, as well as bearing a visually notable structural similarity - yet with just enough fundamental variation from the “prototypical” skeletal structure of the benzodiazepine family to warrant its own distinct category/subcategory, most notably because of it’s pharmacologically novel/unique mechanism of efficacy via binding & potently activating GABA sub-receptors themselves, rather than indirectly positively modulating/up-regulating of the potential of already existing endogenous GABA neurotransmitter’s ability to calm/disinhibit/tranquilize the individual when released.
Beyond this vague, cursory understanding, I had NO prior knowledge of it’s specific merits, advantages, potential as a powerful adjunct to other medical/pharmaceutical therapy, or even it’s family’s very existence/lack of knowledge thereof in the first place. Ive encountered, been prescribed, and know plenty about dozens & dozens of psychoactive substances for anxiety/depression, inflicting their notable pros/cons, general availability, relative strength/typical dosing regimens, whether they are legally controlled substance, and if so, what schedule they belong to, etc etc.
Yet in all of my physician’s appointments, consultations, discussions, changing of medication regimens, etc. this was never even touched upon as a potential solution to even try for short-term relief or to have and use PRN for the most severe/“trying” days/instances of anxiety. In delving into what appears to be a so called “next generation” of benzodiazepine-type molecules, termed “Thienotriazolodiazepines” by several reputable sites, I have found that they possess very similar clinical effects, yet distinct neurological binding sites, and a general potential of anxiety/insomnia relief at least equivalent if not exceeding that of benzodiazepines.
I now have been introduced (compliments of LilRaquel, who began this thread) to an entirely new concept/possible approach of treatment for myself, you really do learn something new every day!
Apologies to LilRaquel for being unable to answer your question personally, at least at present, as well as delving somewhat into the clinical viability of the substance as a mono-therapy, or possible adjunct to an existing regimen of anxiolytics/nighttime sleep aids,” which although not totally on-topic, I feel provides invaluable information/incentive for others in my position - suffering from long-term, severe, daily anxiety in one or more forms, who, despite seeking every legitimate medical approach offered for the above conditions/diagnoses, had never come face to face with this medication/class or sub-class which my hold tremendous therapeutic value for myself and others.
I feel like this is an EXCELLENT, glowing example of why living on the east coast of the United States (Virginia, in specific) is an absolute nightmare if you have chronic health problems, particularly if those problems involve psychoactive chemicals. Should you happen to reside in my neck of the woods, woe to thee, any other Virginians out there know what I mean? I feel your pain and then some!
I’ve been offered legal, ongoing prescriptions for medications as potent as GHB, to deal with the immense amount of anxiety/insomnia & Comorbid depressive episodes I have been through in the past. I declined any prescriptions for barbiturates or other non-benzodiazepine sedatives (GHB being the most alarming/off putting to me), all of which were schedule 2-3 medications vs. the vast majority of the benzodiazepine family being in schedule 4, indiciating less of a psychical and psychological liability. (As it is I am already not thrilled with daily benzodiazapine consumption), cumulative, long-term studies are beginning to reveal more and more damning information regarding long-term consequences of exposure (many have to do with memory, personality, aggression, and impulse control, as well as coordination issues and an increased incidence of serious falls in elderly patients).
Thank you so much for posting this, this is exactly the kind if of information/subject matter that I hold in very high regard, and exactly the kind of mature, responsible, knowledgeable community I have been looking for to share experiences and possible treatment options among other things. Thank you again LilRaquel and to any mods/admins, if you feel this thread had been “hijacked” or substantially “de-railed” to the point of hurting the community/the post, please do not hesitate to delete my comment, or re-direct it/me to a more appropriate place for posting it (I am unsure if I currently have the authority to pin new threads of my own, sorry still getting used to your site).
And in terms of why I am going ahead with making this post here, my reasoning is as follows: As an extreme sufferer of anxiety of all shapes, sizes, and colors so-to-speak, and someone who considers their-self to be at-least reasonably educated about the nature of their own disorder(s) (to the best that science can explain it/them), it is not particularly often when I come across a novel approach, suggestion, technique, treatment, or medication for my illness(s).
Given this is the case for me, I feel it stands to reason that there may be another (or many others) out there who are members (be they relatively new, or older/more established) that might have completely missed this category of medicine, it’s distinctive qualities compared to benzodiazepines, barbiturates, etc., & it’s potentially novel, adjunct, & synergistic treatment(s) of very severe anxiety, (especially when it is severe to the extent where it is downright crippling & presents an enormous obstacle on to roadway to a reasonable quality of life.) If I managed to live for other thirty years without hearing of this treatment due only to where I live and the prevailing state laws within, and if I can enlighten anyone, or merely by suggestion, cause someone to consider something that they might do further research/study on, ask their physician/psychiatrist about, and/or ultimately obtain some psychological, physical, or emotional relief from, cultivating a greater quality of life therein, then I feel obligated to share my own feelings/experiences (in this case, lack thereof) and elaborate as much as possible on said substance vs. it’s alternatives.
To be continued/edited/elaborated on as I learn more, please feel free to
contribute or offer constructive cristicsm,
-Chinchillin
Thienotriazolodiazepines, their uses, merits, detrements, and general distinction from benzodiazepines and other anxiety medications with a similar profile of side effects/effects, but a different chemical receptor binding site and very different pharmacology beneath the surface.
Below is what I had written with the intention of replying to another thread, rather than starting my
Own. If you have personal experience or knowledge of this medication or it’s class/sub-class, I am all ears! I intend to pursue this topic of research on my own, but I also want to benefit/enlighten as many members here as possible as I try to enlighten myself and determine ignorance said substance hasn’t viability as either a mono therapy or an adjunct to my current regimen. Please keep in mind while reading this post that the information below was initially intended as a reply to another thread, and this introduction was actually written last for contex.
As I read and learn more, I will continue to update this thread/edit my posts to reflect greater clarity, accessibility to a wider audience (as little jargon as possible), and in general to be as informative as possible. If something like this exists, please forgive my mistake, I still don’t have access to many features of the site, and I’m not 100% sure of how to cross-check for redundant/duplicate threads that need to be merged. If any of this is an issue please take whatever measures are necessary to right my mistakes and help me understand what I did wrong so I can avoid doing so in the future.
My original message/reaction to the concept of Thienotriazolodiazepines:
________________________________________________________________________________________________
WOW! As a chronic, lifelong sufferer of severe OCD, GAD, Social Anxiety, & Late-waking Insomnia (caused by anxiety... notice a tend? Haha) I’m now an adult patient in my early thirties, and in all my life, I have NEVER encountered this medicine or even class/sub-class in a clinical setting/discussion - though I did recognize it on a surface level, due to having encountered it in an “internet research” context, as well as possibly being advertised via one or more vendors that I’ve had positive working relationships with in the past.
(I will double-check this in case I’m already aware of a potential source that is in stock which may be of immediate aid you and others, though I’m not quite sure how I’d share the information without it being publicly visible/pontentially compromising, and thus it might not be in the best interest of this forum’s loyal & respected membership base as a whole. Furthermore, it being a schedule 1 substance in my state and a handful of others, despite it’s legal potential for prescription federally speaking, state laws greatly limit the likelihood that a vendor
I currently know of would be selling/stocking it)
I recognized it’s name & overall profile via the thread title, as being similar in etymology, chemical profile of physical/psychological effects, as well as bearing a visually notable structural similarity - yet with just enough fundamental variation from the “prototypical” skeletal structure of the benzodiazepine family to warrant its own distinct category/subcategory, most notably because of it’s pharmacologically novel/unique mechanism of efficacy via binding & potently activating GABA sub-receptors themselves, rather than indirectly positively modulating/up-regulating of the potential of already existing endogenous GABA neurotransmitter’s ability to calm/disinhibit/tranquilize the individual when released.
Beyond this vague, cursory understanding, I had NO prior knowledge of it’s specific merits, advantages, potential as a powerful adjunct to other medical/pharmaceutical therapy, or even it’s family’s very existence/lack of knowledge thereof in the first place. Ive encountered, been prescribed, and know plenty about dozens & dozens of psychoactive substances for anxiety/depression, inflicting their notable pros/cons, general availability, relative strength/typical dosing regimens, whether they are legally controlled substance, and if so, what schedule they belong to, etc etc.
Yet in all of my physician’s appointments, consultations, discussions, changing of medication regimens, etc. this was never even touched upon as a potential solution to even try for short-term relief or to have and use PRN for the most severe/“trying” days/instances of anxiety. In delving into what appears to be a so called “next generation” of benzodiazepine-type molecules, termed “Thienotriazolodiazepines” by several reputable sites, I have found that they possess very similar clinical effects, yet distinct neurological binding sites, and a general potential of anxiety/insomnia relief at least equivalent if not exceeding that of benzodiazepines.
I now have been introduced (compliments of LilRaquel, who began this thread) to an entirely new concept/possible approach of treatment for myself, you really do learn something new every day!
Apologies to LilRaquel for being unable to answer your question personally, at least at present, as well as delving somewhat into the clinical viability of the substance as a mono-therapy, or possible adjunct to an existing regimen of anxiolytics/nighttime sleep aids,” which although not totally on-topic, I feel provides invaluable information/incentive for others in my position - suffering from long-term, severe, daily anxiety in one or more forms, who, despite seeking every legitimate medical approach offered for the above conditions/diagnoses, had never come face to face with this medication/class or sub-class which my hold tremendous therapeutic value for myself and others.
I feel like this is an EXCELLENT, glowing example of why living on the east coast of the United States (Virginia, in specific) is an absolute nightmare if you have chronic health problems, particularly if those problems involve psychoactive chemicals. Should you happen to reside in my neck of the woods, woe to thee, any other Virginians out there know what I mean? I feel your pain and then some!
I’ve been offered legal, ongoing prescriptions for medications as potent as GHB, to deal with the immense amount of anxiety/insomnia & Comorbid depressive episodes I have been through in the past. I declined any prescriptions for barbiturates or other non-benzodiazepine sedatives (GHB being the most alarming/off putting to me), all of which were schedule 2-3 medications vs. the vast majority of the benzodiazepine family being in schedule 4, indiciating less of a psychical and psychological liability. (As it is I am already not thrilled with daily benzodiazapine consumption), cumulative, long-term studies are beginning to reveal more and more damning information regarding long-term consequences of exposure (many have to do with memory, personality, aggression, and impulse control, as well as coordination issues and an increased incidence of serious falls in elderly patients).
Thank you so much for posting this, this is exactly the kind if of information/subject matter that I hold in very high regard, and exactly the kind of mature, responsible, knowledgeable community I have been looking for to share experiences and possible treatment options among other things. Thank you again LilRaquel and to any mods/admins, if you feel this thread had been “hijacked” or substantially “de-railed” to the point of hurting the community/the post, please do not hesitate to delete my comment, or re-direct it/me to a more appropriate place for posting it (I am unsure if I currently have the authority to pin new threads of my own, sorry still getting used to your site).
And in terms of why I am going ahead with making this post here, my reasoning is as follows: As an extreme sufferer of anxiety of all shapes, sizes, and colors so-to-speak, and someone who considers their-self to be at-least reasonably educated about the nature of their own disorder(s) (to the best that science can explain it/them), it is not particularly often when I come across a novel approach, suggestion, technique, treatment, or medication for my illness(s).
Given this is the case for me, I feel it stands to reason that there may be another (or many others) out there who are members (be they relatively new, or older/more established) that might have completely missed this category of medicine, it’s distinctive qualities compared to benzodiazepines, barbiturates, etc., & it’s potentially novel, adjunct, & synergistic treatment(s) of very severe anxiety, (especially when it is severe to the extent where it is downright crippling & presents an enormous obstacle on to roadway to a reasonable quality of life.) If I managed to live for other thirty years without hearing of this treatment due only to where I live and the prevailing state laws within, and if I can enlighten anyone, or merely by suggestion, cause someone to consider something that they might do further research/study on, ask their physician/psychiatrist about, and/or ultimately obtain some psychological, physical, or emotional relief from, cultivating a greater quality of life therein, then I feel obligated to share my own feelings/experiences (in this case, lack thereof) and elaborate as much as possible on said substance vs. it’s alternatives.
To be continued/edited/elaborated on as I learn more, please feel free to
contribute or offer constructive cristicsm,
-Chinchillin
