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CBD
#41
https://www.ncbi.nlm.nih.gov/pubmed/29615860

https://www.ncbi.nlm.nih.gov/pubmed/29533978

http://www.cell.com/trends/endocrinology...18)30044-4

Here are a few of the more recent published articles. But the system itself is very complex. If you want the real story from start to today, it started back in the 1960's with a Dr. M from Israel. His work is the forefront of the entire system.
He and an understudy from South America are the top 2 in the world.
If you really want more, its out there and easy to find.

No problems posting things if ya all want, just need to get the time.

Very interesting if you get into that sort of thing.

[Image: ijms-19-00833-g001.png]
(04-10-2018, 11:21 PM)whatapain Wrote: https://www.ncbi.nlm.nih.gov/pubmed/29615860

https://www.ncbi.nlm.nih.gov/pubmed/29533978

http://www.cell.com/trends/endocrinology...18)30044-4

Here are a few of the more recent published articles. But the system itself is very complex. If you want the real story from start to today, it started back in the 1960's with a Dr. M from Israel. His work is the forefront of the entire system.
He and an understudy from South America are the top 2 in the world.
If you really want more, its out there and easy to find.

No problems posting things if ya all want, just need to get the time.

Very interesting if you get into that sort of thing.
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#42
What our government refuses to acknowledge
GW Pharm research - have to thank the UK and Canada
https://www.medicines.org.uk/emc/medicine/23262

Clinical Trials gov future study of US patients still in phase 1 .. we should wonder why this study was put on the back burner, Aug 2017 or perhaps just pending approval once our "regulators" decide how to handle its summary results.

https://clinicaltrials.gov/ct2/show/NCT03245658

The approval of the initiation of this study shows good promise that the US is going to go ahead with further testing in the future..
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#43
The giant photo just shows how cbr1 kinda works with 2AG to assist with neurotransmission. 2AG and CBr1 are agonist - they help each other. CB receptors G x/x have been found in the "protein and fatty" acids of the pre and post synapsis of the neurons.
Since CBr1 is associated with (delta 9) - way over simplified , introduction of higher concentrations of the agonist, increase the "energy exchange" across the membrane.

Since the need for CBr! that is stored "within" the pre and post junctions is decreased due to the introduction of added agonist, CBr1 is released and "acts" upon other receptors within - in the case of the photo- the brain.
So what the xx does that all mean?

If you kinda understand any of that, then the article below is not specific to what I am trying to research but, Is a close study to a problems with the GI tract in the later portion of the article, when it starts to get into CB2r (antagonist to CBr1) and the GI Tract.

If anyone has a theory it would be helpful to know thoughts.
Low dose CBD Oils Basic CBD2 broad spectrum.
IBS, Chrons, Pancreatitis perhaps some cancers.
If inflammation and dysfunction are caused by the body somehow exciting the CBr2 receptors in and around the GI tract for a need for more CBD2 or as the article says CBr1 antagonist (synthesized in the article)
What are the thoughts that an Omega 3 oil infused with CBD ingested would reduce the bodies inflammatory response and dysfunction due to the introduction of increased amounts of CBD2 that the body is looking for.

Based in a lipid It should be able to "adhere" to the tissues that contain receptors?? The gut digests fats, thereby releasing the cbd to be used by the receptors??

Is this sound logic? although theory

Just thinking out loud. wondering others experience.

Interesting reading about digestive functions and theory of the eCBr1 the Munchies some useful GI info about eCBr2

https://reader.elsevier.com/reader/sd/C6...65AB2D96ED
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#44
Great words today from Uncle Don
Federal will not intervene in state matters.
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#45
Whatapain, do you think that CBD for IBS, Chrons, etc. would be more effective dosed orally ?
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#46
no, since it is thought that Chrons affects the entire digestive tract, IBS is most likely the same. Pills and capsules must dissolve ... not something you want to have happen with inflammatory bowel

also
Studies indicate that a delivery of delta 9 and cbn in combination works well, but this is only about supplements not meds.

I hear 30/70 percentage ratio - again supplements not something that you will find on amazon.

delta 9 is known, through validated studies by our government, to reduce nausea, vomiting and promote appetite. Several synthetic Rx meds that are not schedule 1 are available by Rx.

Rectal suppositories are also available for use. They have their benefits. Those who are now producing them either use a vegetable oil, you know that is not desirable or a newer water based.

Water based are still very questionable as the extraction process relies on oils. If someone tries a water based supplement I would recommend the cert of analysis for validation.

CBD infused water may be a good alternative when it comes out, but its going to take large doses. Water is reabsorbed in the large bowel which is a good delivery point for the isolates.

Obvious short answer is no. Not at the moment yet things are changing fast
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#47
Whenever I see a current article regarding a potential new treatment for anxiety relief it gets my attention. This article about CBD Extract was published today on the NPR website. Take a look at:

https://www.npr.org/sections/health-shot...is-extract

For those in the know, I look forward to your feedback.

Raven
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#48
Thats a pretty good article
GW Pharms has been doing much research in the area for seizure disorders in children.
Epidiolex approval is a major hurdle, although the cost is exceptionally hi.
I have no doubts that cannabinoids are an effective and therapeutic supplement for people with PTSD
If you look at seizure disorders and Epidiolex and remember that PTSD is often treated with seizure meds, then the logic that Epidiolex may be useful for PTSD makes sense.

https://www.gwpharm.com/products-pipelin...utic-areas

Here is what GW has been working on..
Canada is taking the lead getting things to market..

[video=youtube]https://youtu.be/xtphZejvGhk[/video]

Dr R's Lecture
Long but more informative than you will find anywhere.
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#49
I love cbd with all my heart, I have tincture that’s 20:1 ratio and take it twice daily mainly for my epilepsy but I know that there’s so many other benefits other then that. I had the worst pain in my elbow almost like a tennis elbow and within two weeks of taking the tincure it completely disappeared. Unfortunately I still take benz0$ for my anxiety but I’m hoping to one day eliminate those with cbd as well.
"If you are at peace, you are living in the present" 
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