Increasing bioavailability of benzo's

[Rafterman]

Since clinical bioavailability studies of benzo's are notoriously inaccurate, the question becomes a more subjective one. It's not really a "one size fits all" thing. I have had the privilege, through my work, of observing the effects of Alp on upwards of 1400 clients (spanning 3 decades). I am also seen it used by friends and family members and I, myself, have been using it for decades for PD and GAD. Since I am smartly not allowed to mention some of the ROA that I have seen used, I will not. I can tell you this, though. I have found that the number one way to increase bioavailability is to take it on an empty stomach. As everyone knows, protein's in the circulatory system compete with benzo's for passage by the blood brain barrier into the brain. When there is nothing else to compete with, the impact is like night and day over someone who has taken them with food. Same could be said of opioids, IMO. Empty stomach not available? Then sub-L would be the go. Every formulation of ALP that I have ever encountered has been lipid-soluble, which means that it will do nicely under the tongue. It's not perfect, as salivary secretions will be begin to break it down if you dawdle, but it sure beats swallowing it on a full stomach. In sum, I believe that an empty stomach trumps an unconventional ROA and also trumps any other substance (Tagamet, grapefruit juice, etc) designed to potentiate benzo's. Just my opinion, though. Your experiences?

For benzos such as clonazepam,ativan,etc. Are available subliminally, but for alpraz. And Diaz. My experience for even just regular oral use for that one second interaction between my taste buds and those substances, it tastes very bitter and unpleasant. Cant imagine fully letting it dissolve sub-l . The bioavailability isnt much higher either usually ubless they are meant to be taken so, from my experience and from research.

Howdy Aquarius,
It's true that there isn't a huge increase in bioavailability by going sub-L, but the difference is enough to be termed "appreciable" by some. After all, if fully dissolved, you are sparing the med the ravages of your digestive system. Every little bit helps. It doesn't compare with the ultimate potentiator, IMO (which I believe is an MT stomach). While they market versions of Ativan and ALP as "sublingual", all lipid-soluble benzo's should be able to be effectively taken that way. Some may have an outer skin (really stupid of the drug manufacturer's to do that because it would be to their benefit to make the meds as soluble as possible). I powder any med that I take sublingually. That defeats the outer shell, if one exists. People usually dislike the bitterness, but I have seen some come to actually like it (long term users who come to associate that bitterness with the relief that is soon on it's way). Funny how the mind works. Cheers.  RM