12-09-2016, 01:50 AM
It is relative contradiction to take tram with other SSRI , since there is the risk of serotonin syndrome. It is rare but can happen. Tramadol is an analgesic medication with partial mu agonist activity and affects serotonin and norepinephrine. Toxicity from tramadol appears to be due to monoamine uptake inhibition rather than its opioid effects. It is relative safe as it is not causing so much respiratory depression as other opoioids. But there are common side effects less severe like those you describe when using tram with antidepressants. In addition recent reports claim increased side effects for Tram when combined with hydrocodone. But the real risk is seizures which is true when you go above 400 mg quick.